Xeris Biopharma (NASDAQ:XERS) and Amylyx Pharmaceuticals (NASDAQ:AMLX) Financial Contrast

Xeris Biopharma (NASDAQ:XERS) and Amylyx Pharmaceuticals (NASDAQ:AMLX) are both small-cap medical companies, but which is the superior business? We will compare the two businesses based on the strength of their profitability, dividends, institutional ownership, analyst recommendations, valuation, earnings and risk.

Profitability

This table compares Xeris Biopharma and Amylyx Pharmaceuticals’ net margins, return on equity and return on assets.

	Net Margins	Return on Equity	Return on Assets
Xeris Biopharma	3.81%	735.00%	3.24%
Amylyx Pharmaceuticals	N/A	-55.69%	-50.73%

Volatility & Risk

Xeris Biopharma has a beta of 0.85, indicating that its stock price is 15% less volatile than the S&P 500. Comparatively, Amylyx Pharmaceuticals has a beta of -0.16, indicating that its stock price is 116% less volatile than the S&P 500.

Analyst Ratings

This is a breakdown of current recommendations and price targets for Xeris Biopharma and Amylyx Pharmaceuticals, as provided by MarketBeat.com.

	Sell Ratings	Hold Ratings	Buy Ratings	Strong Buy Ratings	Rating Score
Xeris Biopharma	1	2	4	0	2.43
Amylyx Pharmaceuticals	1	2	8	1	2.75

Xeris Biopharma currently has a consensus target price of $10.80, suggesting a potential upside of 80.00%. Amylyx Pharmaceuticals has a consensus target price of $23.00, suggesting a potential upside of 73.06%. Given Xeris Biopharma’s higher probable upside, analysts plainly believe Xeris Biopharma is more favorable than Amylyx Pharmaceuticals.

Insider and Institutional Ownership

42.8% of Xeris Biopharma shares are owned by institutional investors. Comparatively, 95.8% of Amylyx Pharmaceuticals shares are owned by institutional investors. 6.5% of Xeris Biopharma shares are owned by insiders. Comparatively, 10.9% of Amylyx Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that endowments, hedge funds and large money managers believe a company is poised for long-term growth.

Earnings & Valuation

This table compares Xeris Biopharma and Amylyx Pharmaceuticals”s gross revenue, earnings per share and valuation.

	Gross Revenue	Price/Sales Ratio	Net Income	Earnings Per Share	Price/Earnings Ratio
Xeris Biopharma	$314.85 million	3.29	$550,000.00	$0.06	100.00
Amylyx Pharmaceuticals	$87.37 million	16.91	-$144.74 million	($1.50)	-8.86

Xeris Biopharma has higher revenue and earnings than Amylyx Pharmaceuticals. Amylyx Pharmaceuticals is trading at a lower price-to-earnings ratio than Xeris Biopharma, indicating that it is currently the more affordable of the two stocks.

Summary

Xeris Biopharma beats Amylyx Pharmaceuticals on 9 of the 15 factors compared between the two stocks.

About Xeris Biopharma

Xeris Biopharma Holdings, Inc., a biopharmaceutical company, engages in developing and commercializing therapies in Illinois. The company offers Gvoke, a ready-to-use liquid-stable glucagon for the treatment of severe hypoglycemia pediatric and adult patients; Keveyis, a therapy for the treatment of hyperkalemic, hypokalemic, and related variants of primary periodic paralysis; and Recorlev, a cortisol synthesis inhibitor proved for the treatment of endogenous hypercortisolemia in adult patients with Cushing's syndrome. It is also developing XP-8121, a once-weekly subcutaneous injection of levothyroxine that is in phase I clinical trial for the treatment of hypothyroidism; and non-aqueous XeriSol and XeriJect technologies for various therapies. The company was incorporated in 2005 and is headquartered in Chicago, Illinois.

About Amylyx Pharmaceuticals

Amylyx Pharmaceuticals, Inc., a commercial-stage biotechnology company, engages in the discovery and development of treatment for amyotrophic lateral sclerosis (ALS) and neurodegenerative diseases. The company's products include RELYVRIO, a dual UPR-Bax apoptosis inhibitor composed of sodium phenylbutyrate and taurursodiol for the treatment of ALS in adults in the United States and marketed as ALBRIOZA for the treatment of ALS in Canada. It is also developing AMX0114 for other neurodegenerative diseases. Amylyx Pharmaceuticals, Inc. was founded in 2013 and is headquartered in Cambridge, Massachusetts.