Marinus Pharmaceuticals (MRNS) vs. Zafgen (ZFGN) Head to Head Contrast

Zafgen (NASDAQ: ZFGN) and Marinus Pharmaceuticals (NASDAQ:MRNS) are both small-cap medical companies, but which is the superior stock? We will compare the two companies based on the strength of their analyst recommendations, earnings, profitability, valuation, risk, institutional ownership and dividends.

Volatility & Risk

Zafgen has a beta of -0.55, meaning that its share price is 155% less volatile than the S&P 500. Comparatively, Marinus Pharmaceuticals has a beta of 2.6, meaning that its share price is 160% more volatile than the S&P 500.

Valuation and Earnings

This table compares Zafgen and Marinus Pharmaceuticals’ gross revenue, earnings per share (EPS) and valuation.

Gross Revenue Price/Sales Ratio Net Income Earnings Per Share Price/Earnings Ratio
Zafgen N/A N/A -$52.02 million ($1.90) -3.59
Marinus Pharmaceuticals N/A N/A -$18.89 million N/A N/A


This table compares Zafgen and Marinus Pharmaceuticals’ net margins, return on equity and return on assets.

Net Margins Return on Equity Return on Assets
Zafgen N/A -66.22% -54.53%
Marinus Pharmaceuticals N/A -41.07% -38.45%

Insider and Institutional Ownership

52.2% of Zafgen shares are held by institutional investors. Comparatively, 63.6% of Marinus Pharmaceuticals shares are held by institutional investors. 23.7% of Zafgen shares are held by insiders. Comparatively, 4.6% of Marinus Pharmaceuticals shares are held by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a stock is poised for long-term growth.

Analyst Ratings

This is a summary of current ratings and target prices for Zafgen and Marinus Pharmaceuticals, as reported by MarketBeat.

Sell Ratings Hold Ratings Buy Ratings Strong Buy Ratings Rating Score
Zafgen 0 1 1 0 2.50
Marinus Pharmaceuticals 0 0 4 0 3.00

Zafgen presently has a consensus price target of $20.00, indicating a potential upside of 193.26%. Marinus Pharmaceuticals has a consensus price target of $18.75, indicating a potential upside of 303.23%. Given Marinus Pharmaceuticals’ stronger consensus rating and higher probable upside, analysts clearly believe Marinus Pharmaceuticals is more favorable than Zafgen.


Marinus Pharmaceuticals beats Zafgen on 8 of the 9 factors compared between the two stocks.

Zafgen Company Profile

Zafgen, Inc., a clinical-stage biopharmaceutical company, develops therapies for patients suffering from metabolic diseases comprising type 2 diabetes, Prader-Willi syndrome (PWS), and other metabolically related disorders. The company's lead product candidate is ZGN-1061, a fumagillin-class methionine aminopeptidase 2 (MetAP2) inhibitor administered by subcutaneous injection, which is in Phase 2 clinical trial and profiled for its utility in the treatment of type 2 diabetes and other related metabolic disorders. It also develops ZGN-1258, a MetAP2 inhibitor for treatment of PWS. Zafgen, Inc. was founded in 2005 and is headquartered in Boston, Massachusetts.

Marinus Pharmaceuticals Company Profile

Marinus Pharmaceuticals, Inc., a biopharmaceutical company, focuses on developing and commercializing therapeutics to treat epilepsy and neuropsychiatric disorders. Its clinical stage product candidate, ganaxolone, is an allosteric modulator of GABAA, developed in three different dose forms: intravenous (IV), capsule, and liquid. The multiple dose forms are intense to maximize the therapeutic range of ganaxolone for adults and pediatric patients. Ganaxolone acts as an anti-seizure, anti-anxiety, and anti-depressive actions; and acts on synaptic and extra synaptic GABAA receptors. The company is also developing ganaxolone for pediatric refractory epilepsy; postpartum depression; and acute epilepsy, which are in Phase II clinical study. In addition, it is developing ganaxolone IV formulation to treat status epilepticus. Marinus Pharmaceuticals, Inc. has a collaboration agreement with NovaMedica, LLC; and license agreements with Purdue Neuroscience Company and CyDex Pharmaceuticals, Inc. The company was founded in 2003 and is based in Radnor, Pennsylvania.

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